Vaginal micronised progesterone: what to know

Vaginal micronised progesterone is prescribed for specific fertility or hormone-therapy plans, and its dose and timing must follow your clinician’s instructions. It supports progesterone activity in the reproductive system, but the reason for use determines how it is given and how long it is continued. Do not start, stop or change it without advice.

Progesterone helps prepare and maintain the lining of the uterus. In fertility care, vaginal progesterone may support the uterine lining around embryo transfer, including a frozen embryo transfer plan. In menopause care, progesterone may be paired with oestrogen in hormone replacement therapy when protection of the uterine lining is needed. These uses are different, so another person’s schedule is not a safe guide for yours.

Use the prescribed capsule or preparation exactly as directed, usually inserting it into the vagina with clean hands at the scheduled time. Some leakage or residue can occur afterwards; a panty liner may help. Keep track of missed doses and ask the prescribing team what to do rather than doubling up. Tell them about other medicines, allergies, unexpected bleeding and any possibility of pregnancy. Store it as directed and keep it away from children.

Get urgent help for chest pain, sudden breathlessness, coughing blood, one-sided leg swelling or pain, fainting, severe headache, weakness or speech trouble. Contact the prescribing team promptly for heavy or unexpected bleeding, severe abdominal pain, a concerning allergic reaction or symptoms that are difficult to tolerate. In fertility treatment, follow the clinic’s instructions about pregnancy testing and medication continuation.

Ask what the medicine is supporting, when to insert it, how long to continue, and what to do after a missed dose. Check whether intercourse, vaginal products or other medicines affect use. Ask which bleeding or pain symptoms require an urgent call.