What should you know about GLP-1 agonist therapy?

GLP-1 agonist therapy can help selected people manage blood glucose, appetite and weight alongside an individual care plan. These medicines act on hormone pathways involved in insulin release, digestion and hunger. They are prescribed for particular medical needs, not as a general substitute for nutrition, activity or follow-up.

A [GLP-1 Receptor Agonist](/materials/glp-1-receptor-agonist/) can increase insulin release when blood glucose is raised, reduce glucagon signalling, and slow movement of food from the stomach. People may feel full sooner and eat less. Different medicines, doses and delivery schedules suit different patients. Treatment may be considered for [Type 2 Diabetes](/conditions/type-2-diabetes/) or [Obesity](/conditions/obesity/), depending on health history and local prescribing decisions.

Use the prescribed dose and schedule, and never share injection devices. Keep appointments so glucose, weight, hydration and side effects can be reviewed. Nausea, vomiting, diarrhoea, constipation or reduced appetite can occur, particularly when treatment starts or the dose changes. Drink as advised and tell the prescriber if you cannot keep fluids down. A [Weight Management Programme](/treatments/lifestyle-and-wellness/weight-management-programme/) can provide practical support with meals, movement and habits.

Seek urgent medical advice for severe or persistent abdominal pain, repeated vomiting, faintness, signs of dehydration, trouble breathing, facial swelling or a widespread rash. Contact your care team about ongoing digestive symptoms, low blood glucose symptoms, or a sudden change in your ability to eat or drink. Unexplained weight change should be assessed rather than assumed to be a treatment effect; see [Unexplained Weight Gain](/symptoms/unexplained-weight-gain/) for a related concern.

Ask which goal the medicine addresses, how dose changes work, what to do after a missed dose, and how it interacts with your other medicines. Mention pregnancy plans, previous pancreatic or gallbladder problems, kidney concerns and any severe digestive symptoms before treatment begins.