What should you know about CDKN2A melanoma?

CDKN2A helps regulate how cells divide. A harmful inherited change may be passed through a family and can make melanoma more likely than in people without that susceptibility. It does not mean that every person with the change will develop cancer, and it does not identify whether a particular mole is melanoma. A genetics professional can explain testing, family implications and the difference between an inherited finding and a change found only in tumour cells.

Arrange a dermatology assessment for a baseline examination and a personalised monitoring plan. Check your skin regularly for a new or changing mole, uneven colour, an irregular border, growth, bleeding or a sore that does not heal; photograph changes only as an aid, not as a substitute for examination. Protect skin from ultraviolet exposure with shade, clothing and sunscreen. If a suspicious lesion is identified, the clinician may recommend Surgical Excision and, depending on the melanoma details, a Sentinel Lymph Node Biopsy. Family members may be offered genetic counselling.

Request prompt assessment for a changing, bleeding, itching or rapidly growing mole, or a new dark mark that looks different from your other spots. Urgent medical attention is appropriate for severe symptoms such as new weakness, confusion, seizures or a sudden severe headache, which can have many causes but should not be ignored.

Ask whether genetic counselling is appropriate, how often your skin should be examined, which relatives may benefit from advice, and what biopsy or treatment would fit any changing lesion.