What should you know about Zoladex and letrozole?

Zoladex is a goserelin injection that temporarily switches off ovarian hormone production in many premenopausal patients. Letrozole is an aromatase inhibitor: it reduces the body’s production of oestrogen from other tissues. Using an aromatase inhibitor while the ovaries remain active may not provide the intended hormone suppression, which is why the medicines can be paired in selected situations.

The plan depends on cancer biology, menopausal status, prior treatment, and health history. Explore <a href="/materials/aromatase-inhibitor-drugs/">Aromatase Inhibitor Drugs</a> and <a href="/treatments/systemic-therapy/aromatase-inhibitor-therapy/">Aromatase Inhibitor Therapy</a>.

Attend injection appointments and take letrozole on the schedule provided. Report hot flushes, night sweats, joint or muscle aches, low mood, vaginal symptoms, or changes in bleeding. Your clinician may monitor bone health, blood pressure, cholesterol, and other factors based on your treatment plan.

Tell the team about pregnancy possibility, contraception, breastfeeding, fractures, liver problems, and all medicines or supplements. Do not stop either medicine because of side effects without discussing alternatives or supportive measures.

Contact your treatment team promptly for heavy or unexpected bleeding, severe depression, a new severe headache, marked weakness, or symptoms after an injection that concern you. Seek urgent help for chest pain, sudden breathlessness, one-sided weakness, or swelling and pain in a limb. These symptoms require assessment rather than a medication change made alone.

Ask why both medicines are recommended, how ovarian suppression will be checked, how long treatment may continue, and which side effects should be reported the same day. Ask about bone-strength monitoring, contraception, managing joint symptoms, missed doses, and what happens if an injection or tablet is delayed.