Why is clomifene citrate used in ovulation induction?

Clomifene changes how the brain senses oestrogen. In response, the pituitary gland can release more follicle-stimulating and luteinising hormones. These signals may help an ovarian follicle grow and trigger ovulation when ovulation is irregular or absent.

It is not suitable for every cause of difficulty conceiving. A fertility clinician may first assess menstrual history, hormone patterns, ovarian function, the womb and fallopian tubes, and sperm factors. The aim is to choose treatment that matches the reason ovulation is not occurring.

Take clomifene only on the days and at the dose prescribed. Your clinic may use scans, hormone tests, or cycle tracking to see how your ovaries respond and to help identify the fertile window. Do not add extra tablets if ovulation does not occur.

Read about the medicine in [Clomifene Citrate](/materials/clomifene-citrate/) and the treatment pathway in [Ovulation Induction](/treatments/fertility-and-assisted-reproduction/ovulation-induction/). Tell the clinic about other medicines and any chance of pregnancy before starting another course.

Contact your fertility team promptly for severe pelvic pain, marked abdominal swelling, breathing difficulty, faintness, or visual symptoms. These symptoms need assessment during fertility treatment.

Tell the clinic if you have unusual bleeding, a positive pregnancy test, or symptoms that concern you. They can advise whether to continue, pause, or change the plan.

Ask why clomifene is appropriate for your ovulation pattern, how response will be monitored, when intercourse or insemination is advised, and what happens if ovulation does not occur. Ask about alternatives and the symptoms that require an urgent call.