Why does multiple myeloma cause persistent bone pain?

Persistent Bone Pain is a very common presentation of Multiple Myeloma. Myeloma cells can release signals that increase bone breakdown while reducing the normal rebuilding response. This may create weakened areas, often in the spine, ribs, pelvis, or other load-bearing bones. Pain can feel deep and aching, remain in one area, or worsen with movement, coughing, or turning in bed.

Bone pain has other possible explanations, including injury, arthritis, infection, and osteoporosis. A clinical assessment may include questions about pain and movement, blood tests, and imaging. The pattern of pain cannot diagnose myeloma on its own, but a new or changing symptom deserves attention.

Tell your haematology team where the pain is, whether it is new, and how it affects sleep or movement. Report falls, sudden pain, height change, weakness, tingling, or numbness. Protect a painful area from heavy lifting and unplanned impact until it is assessed. Take prescribed pain relief as directed and check before using anti-inflammatory medicines or supplements, particularly if you have kidney problems or other treatments.

Seek urgent care for sudden severe back or limb pain, inability to move, new weakness, numbness, or loss of bladder or bowel control. These signs can occur with a fracture or pressure on the spinal cord. Contact the treating team promptly for pain that is escalating, pain after a small injury, repeated falls, confusion, severe thirst, or reduced urination.

Could this pain indicate a weakened bone or fracture? Do I need imaging or blood tests? Which pain medicines are suitable for my kidneys and current treatment? Should I change lifting or exercise? What symptoms mean I should attend urgent care?