What should you know about SSRI rash?

A rash after starting or changing a selective serotonin reuptake inhibitor may reflect a drug eruption, irritation, or an unrelated problem. Look for timing, itch, raised areas, scaling, blisters, or involvement of the mouth and eyes. Do not assume every rash is caused by the medicine: atopic dermatitis, contact dermatitis, heat rash, psoriasis, ringworm, scabies, and intertrigo can look different but may be confused at first.

Contact the prescriber promptly with the medicine name, dose, start date, recent dose changes, and a description or photograph of the rash. Do not stop an SSRI suddenly without medical advice, because withdrawal symptoms and return of the treated condition can occur. Until assessed, avoid new creams, fragranced products, and scratching; keep the skin cool and gently cleansed.

Seek urgent medical care for facial or tongue swelling, trouble breathing, faintness, widespread blistering, skin pain, peeling, sores in the mouth or eyes, fever, or rapidly worsening redness. These features can signal a serious reaction and should not wait for a routine appointment.

Could this be a drug eruption or another skin condition? Should my SSRI be continued, changed, or tapered? Which symptoms mean I should seek emergency help? Is a skin examination or referral needed?