Progressive Glioblastoma

Glioblastoma can progress within or near the original treatment area, and it can affect movement, speech, memory, vision, behaviour, or seizure control. The team compares current scans with earlier images and considers steroid use, symptoms, treatment timing, and examination findings. Changes on imaging can sometimes be difficult to interpret, so the clinician may recommend further review or imaging.

Possible next steps include surgery for selected tumours, radiotherapy, chemotherapy, a clinical trial, or symptom-focused care. The choice depends on tumour location, prior treatment, functional ability, medicines, and what matters most to the patient.

Keep a daily note of headaches, seizures, speech or memory changes, weakness, balance, sleepiness, and steroid effects. Take anti-seizure and steroid medicines exactly as prescribed, and do not stop steroids suddenly without medical advice. Ask about rehabilitation, home safety, work, driving, and help with personal care.

Get urgent help for a first seizure, a seizure lasting longer than usual, sudden weakness, new trouble speaking, severe worsening headache, repeated vomiting, marked confusion, or difficulty waking. These symptoms can reflect swelling, seizure activity, bleeding, or another neurological emergency.

What has changed on the scan, and how confident is that interpretation? Where is the tumour located in relation to speech, movement, or vision areas? What is the goal of each option? Would surgery, radiotherapy, chemotherapy, or a clinical trial be suitable? Which symptoms require immediate help?