Non-invasive PGT-A

Non-invasive PGT-A analyses genetic material released into the fluid around an embryo rather than removing a cell from the embryo itself. The result may not represent every cell in the embryo.

PGT-A means preimplantation genetic testing for aneuploidy. Embryos are created during IVF, developed in a laboratory, and tested before a transfer decision. A non-invasive sample comes from the culture fluid. Methods such as [Next-Generation Sequencing](/technology/next-generation-sequencing/) may read this material, but the result is not a diagnosis of a child and cannot predict every health condition.

Ask how the sample is collected, which result categories are reported, and what happens when the result is unclear. Discuss conventional [PGT-A](/treatments/fertility-and-assisted-reproduction/pgt-a/) or no testing as alternatives. Ask how results fit with embryo quality, medical history, and your reproductive goals. Genetic counselling can help with consent and interpretation.

Contact the fertility clinic promptly for severe pain, heavy bleeding, fever, fainting, or breathing difficulty after egg collection or embryo transfer. Seek clarification before a transfer decision if a report is inconclusive or conflicts with other findings. A screening result cannot guarantee implantation or a healthy pregnancy.

Ask: What material is tested? How could contamination affect interpretation? What happens if no result is obtained? Will testing change which embryo is offered first? What prenatal testing will still be offered?