Hepatitis B immunoglobulin after an exposure

Post-exposure immunoglobulin is considered after contact with blood or other material that could carry hepatitis B. It works by providing antibodies quickly, whereas vaccination helps the immune system develop its own response. The decision depends on the type of exposure, the source person’s status, and your previous vaccine record.

It is not a substitute for medical review or for completing a recommended vaccine course. Information about [Hepatitis B](/conditions/hepatitis-b/) can help you understand the infection.

Wash exposed skin with soap and water; flush splashes to the eyes or mouth with clean water. Do not squeeze a puncture wound or apply harsh chemicals. Contact an emergency department or occupational-health service promptly, taking details of the exposure and your vaccination history. The team may arrange immunoglobulin, vaccination, and follow-up blood tests.

Record when and how the contact occurred, whether skin was broken, and whether protective equipment was used. If symptoms later appear, a [Liver Function Test](/treatments/diagnostics-and-screening/liver-function-test/) may be included in assessment.

Get immediate help for a severe allergic reaction after treatment, including breathing trouble, throat swelling, fainting, or widespread hives. Seek medical care for yellow eyes, dark urine, severe abdominal pain, repeated vomiting, or unusual exhaustion after an exposure. Symptoms do not reliably show whether exposure occurred, so do not wait for them before reporting contact.

Ask whether the exposure qualifies for immunoglobulin, whether you need hepatitis B vaccination, which blood tests are planned, and when results or follow-up appointments will be reviewed.