What should you know about glutathione mesotherapy for melasma?

Melasma causes patchy brown or grey-brown facial pigmentation and can resemble other conditions. Mesotherapy uses multiple small needle punctures to deliver a preparation into the skin. The product may contain glutathione alone or additional ingredients, so ask for the complete list. Needling can cause temporary redness, tenderness, swelling, bruising, or irritation; inflammation can make pigmentation look darker in some skin types. Results are not predictable and melasma can recur.

Have the pigmentation diagnosed before treatment, especially if it is new, one-sided, itchy, bleeding, or changing. Ask about pregnancy, breastfeeding, active acne, eczema, cold sores, allergies, and medicines that affect healing or bleeding. Use the advised gentle skin care and broad-spectrum sun protection after treatment. Avoid picking, scrubbing, or adding irritating products until the skin settles.

Seek urgent help for breathing difficulty, facial swelling, widespread hives, fainting, or rapidly worsening symptoms. Contact the clinic for increasing pain, warmth, pus, fever, blistering, or pigment change that continues or expands.

Ask how melasma was confirmed, what is injected, how the skin will be protected from inflammation, what alternatives are available, and how recurrence or a poor response will be managed.