Roaccutane pill: how it works and what to expect

Isotretinoin reduces oil production and changes how skin cells and inflammation contribute to severe acne. The skin and lips often become dry, and eyes or the nose may feel irritated. Acne can look different during the early part of treatment before improvement becomes clearer. The medicine is prescribed for a specific person, so another person’s capsules or dose are not appropriate.

Your clinician may review your health, medicines and blood tests before or during treatment. Tell them about liver problems, high blood fats, mood symptoms, allergies and any vitamin A product. Read about [Isotretinoin Treatment](/treatments/medical-dermatology/isotretinoin-therapy/) and [Pimples](/symptoms/pimples/).

Take the capsule exactly as labelled and follow the instructions about food. Use gentle cleanser, moisturiser, lip balm and sun protection; avoid harsh scrubs, waxing and unapproved supplements. Do not donate blood while taking it. Attend follow-up appointments, report new symptoms early and tell every healthcare professional that you use isotretinoin.

Contact your clinician promptly for severe or persistent headache, vision changes, intense abdominal pain, yellowing of the skin or eyes, marked mood change or thoughts of self-harm. If pregnancy is possible, stop and seek urgent medical advice because isotretinoin can seriously harm an unborn baby.

Ask why isotretinoin is being recommended, how your dose will be adjusted, which tests are needed, how to manage dryness, and which medicines or supplements must be avoided.