How is G6PD deficiency treated?

G6PD deficiency is inherited, so treatment does not replace the missing enzyme. Many people manage it by learning which medicines, chemicals, and foods may trigger red blood cell breakdown and by telling healthcare professionals about the diagnosis. Infections can also trigger haemolysis and should be assessed early. During an episode, clinicians check the blood count, bilirubin, urine, and kidney function. Care may include fluids, observation, treatment of the trigger, or hospital support when anaemia is severe.

Carry a written diagnosis or medical alert and check every new medicine with a clinician or pharmacist. Do not start, stop, or substitute a medicine based on an online list alone. Attend follow-up testing when advised, especially after an episode. A [Blood Test](/treatments/diagnostics-and-screening/blood-test/) can help assess enzyme activity and the effects of haemolysis.

Seek urgent assessment for sudden severe tiredness, breathlessness, dizziness, fainting, yellow eyes, very dark urine, or rapidly worsening pallor. These signs may mean red blood cells are breaking down quickly. More information is available about [Dark Urine](/symptoms/dark-urine/) and [Pale Skin](/symptoms/pale-skin/).

Ask for a personalised trigger list, an emergency plan for fever or infection, and guidance on medicines commonly used for you. Ask whether family members should be tested and when follow-up blood work is needed.