Oestradiol

Oestradiol is an oestrogen hormone used to replace or supplement oestrogen in selected treatments.

Oestradiol is the main oestrogen hormone made by the ovaries during the reproductive years. It helps influence the menstrual cycle and supports tissues such as the vagina, uterus and bones. Levels commonly change around menopause, which can contribute to hot flushes, night sweats, vaginal dryness and changes in bleeding patterns.

Oestradiol attaches to oestrogen receptors in different tissues. The effect depends on the dose, the route used and whether treatment acts throughout the body or mainly in the vaginal area. It may be supplied as a tablet, patch, gel, spray, cream, pessary or ring, depending on the treatment plan.

Oestradiol may be part of Hormone Replacement Therapy for menopause symptoms when a clinician considers it suitable. Low-dose vaginal forms may be used for vaginal dryness, irritation or discomfort linked with reduced oestrogen. Treatment choice takes account of symptoms, medical history, the presence of a uterus and any other medicines.

Some people manage menopause symptoms with non-hormonal medicines, moisturisers, lubricants, lifestyle changes or treatment aimed at a particular symptom. The suitable option depends on the symptom and health history; a clinician can compare expected benefits, precautions and practical choices.

The same word, oestradiol, can describe treatments with very different routes and purposes. Ask which product you have, where it is meant to act, how often to use it and what to do after a missed dose. New or unexpected vaginal bleeding, breast changes, severe headache, chest pain, breathlessness or one-sided leg swelling needs prompt medical advice.

A review helps confirm that the treatment still matches your symptoms and health needs. Keep follow-up appointments, use the prescribed amount and mention migraines, blood clots, liver disease, unexplained bleeding or a history of hormone-sensitive cancer before starting or changing oestradiol. Do not stop or alter treatment without advice if symptoms return or side effects appear.