Clotrimazole: what it is and how it is used

Clotrimazole is an antifungal medicine that slows or stops the growth of fungi on or in the body.

It belongs to a group of medicines that interfere with the fungal cell membrane. This can reduce the fungal growth responsible for symptoms such as itching, soreness or unusual discharge when a clinician has identified a fungal cause. Clotrimazole does not treat every cause of vaginal irritation, so the diagnosis matters.

The medicine may be supplied as a cream, a vaginal tablet or another preparation, depending on the body area and the product prescribed or recommended. The form affects where it is placed and how it is used; it does not make every product interchangeable.

Some preparations are intended for external skin, while others are designed for use inside the vagina. Read the product directions and check the active ingredient before applying it. Keep it away from the eyes and do not swallow a product intended for skin or vaginal use.

In women’s health, clotrimazole is commonly associated with treatment for vaginal thrush, a fungal infection. An external cream may be used on irritated outer skin, while an internal preparation may be selected for vaginal symptoms. The correct choice depends on the site and the clinical assessment.

For more detail about how this medicine fits into care for thrush, see the [Antifungal Treatment for Thrush](/treatments/medical-gynaecology/antifungal-treatment-for-thrush/) page.

Other antifungal medicines may be considered when clotrimazole is unsuitable, unavailable or has not helped. A clinician may also choose a different formulation or treatment duration. If symptoms keep returning, an assessment can check whether the problem is another infection, irritation or a skin condition rather than uncomplicated thrush.

Use clotrimazole only in the way stated on its label or explained by a healthcare professional. Complete the recommended course unless you are told to stop, and avoid introducing other products that may irritate the area. Seek medical advice if symptoms worsen, do not improve, recur often, or include bleeding, pelvic pain, fever or a strong-smelling discharge.

Store the product according to its packaging, keep it out of children’s reach and check the expiry date. Wash hands before and after use. Tell a clinician or pharmacist about pregnancy, breastfeeding, allergies and other medicines, because the appropriate formulation and advice can differ.