Multiple myeloma and kidney stones

A kidney stone is a solid deposit that can move through the urinary tract and cause sharp pain in the side or back, nausea, or blood in the urine. Multiple myeloma can affect kidney filtering through abnormal proteins or high calcium released from bone; this may cause thirst, dehydration, reduced urine, swelling, or confusion and may occur without stone-like pain. A person can have stones for reasons unrelated to myeloma, while similar symptoms can also come from infection or another kidney problem.

Tell the clinician where the pain is, whether it comes in waves, how urine has changed, and whether fever, vomiting, thirst, or constipation is present. Assessment may include blood tests for kidney function and calcium, urine testing, and imaging. Drink according to the advice given for your health and kidney function; do not force fluids if you have been told to restrict them. If myeloma is present, care may include [Targeted Therapy](/treatments/systemic-therapy/targeted-therapy/) or [Chemotherapy](/treatments/systemic-therapy/chemotherapy/), while [Bone-Strengthening Therapy](/treatments/supportive-and-palliative-care/bone-strengthening-therapy/) may be considered for bone effects.

Seek urgent care for severe or unrelenting side pain, fever with urinary symptoms, repeated vomiting, very little urine, or visible blood in urine. Emergency help is needed for confusion, fainting, severe weakness, or difficulty breathing. A blocked urinary tract, infection, dehydration, high calcium, or acute kidney injury can require rapid treatment.

Ask whether testing shows a stone, myeloma-related kidney stress, infection, or another cause; which pain medicines are suitable; how much fluid is right for you; and when kidney function should be rechecked. Ask which symptoms mean you should go straight to emergency care.