What should you know about melatonin and melanoma?

Melatonin is made mainly by the body in response to darkness and is also sold as a supplement in some settings. Melanoma begins in melanocytes, the cells that produce pigment, and may arise in an existing mole or on previously normal skin. Melatonin itself should not be treated as a diagnosis or as a substitute for examination of a changing mark.

A concerning skin lesion may show evolving colour, shape, size or surface, but appearance cannot confirm cancer. A clinician may use dermoscopy and arrange a biopsy when needed. Do not delay review because a supplement seems relevant.

Check any changing mole or new persistent pigmented spot with a dermatologist. Take a clear record of when the change began and bring a list of medicines and supplements, including melatonin, to the appointment. Avoid picking or attempting to remove a lesion at home.

If melanoma is diagnosed, care may include Surgical Excision and, when clinically indicated, Sentinel Lymph Node Biopsy. More advanced disease can involve treatments such as Immunotherapy, with follow-up tailored to the pathology and stage.

Arrange prompt dermatology review for a lesion that changes noticeably, bleeds, crusts, itches persistently or develops an irregular edge or multiple colours. Seek urgent medical help for severe symptoms such as new neurological problems in a person already being treated for melanoma. A skin change should be assessed on its own features, not explained by the similar wording of melatonin.

Ask whether a lesion needs dermoscopy or biopsy, whether any supplement should be paused, and what the pathology shows. If melanoma is confirmed, ask about the purpose of surgery, staging tests, Immunotherapy and the follow-up schedule.