What should you know about luteal phase support frozen embryo transfer?

Progesterone changes the uterine lining after ovulation and helps coordinate the timing between the lining and embryo. In a natural frozen embryo transfer cycle, the body may make progesterone after ovulation. In a hormone-prepared cycle, or when the clinic wants additional support, micronised progesterone may be prescribed through the vagina, by mouth, or in another form according to the protocol. The start date and duration are part of the transfer plan, not details to adjust independently.

Use the prescribed dose at the stated times and ask what to do if a dose is late, missed, or comes out after vaginal use. Keep taking it until the fertility team tells you to stop, including after an early pregnancy test unless instructed otherwise. Mild discharge, breast tenderness, bloating, tiredness, or mood changes can occur with progesterone. Keep the clinic informed about other medicines and any bleeding, pain, or new symptoms.

Contact the fertility team for bleeding, increasing pelvic pain, fever, or concerns about a missed dose. Seek urgent help for severe one-sided pain, heavy bleeding with dizziness or fainting, chest pain, or difficulty breathing. Do not stop progesterone because of spotting without discussing it with the clinic; they can explain whether examination or testing is needed.

Ask whether your cycle is natural, modified, or hormone-prepared, why progesterone is recommended, and which route is planned. Confirm when support starts, how long it continues, when pregnancy testing is arranged, and what to do after spotting, a missed dose, or a negative result.