How do topical calcineurin inhibitors work?

Tacrolimus ointment and pimecrolimus cream enter local skin cells and reduce activation of inflammatory T-cell signals. As inflammation settles, redness, itch, and irritation can ease. They are often considered for sensitive or thin-skinned areas, such as the face, eyelids, neck, and skin folds, when a clinician feels they are suitable. They do not act like a moisturiser and do not repair every cause of a colour change or rash. A brief warm, stinging, or burning feeling can happen when treatment begins, especially on actively inflamed skin.

Apply a thin layer exactly as prescribed to affected skin, avoiding the eyes, mouth, and broken skin unless specifically instructed. Continue gentle moisturising and use sun protection, because treated skin may be more sensitive to sunlight. Do not cover the area with an airtight dressing unless your clinician tells you to. Tell the prescriber about infections, cold sores, immune problems, pregnancy, and other creams. Improvement may take time, and stopping or restarting should follow the treatment plan.

Ask for a review if burning is severe or persistent, the rash worsens, or treated skin develops crusting, blisters, pus, or painful grouped spots. Seek prompt care for a spreading infection, fever, or eye involvement. A rash that does not respond may need a different diagnosis or treatment rather than repeated applications.

Which diagnosis is this treating, and where should I apply the medicine? When should I expect less itch? What should I do if I develop a cold sore, infection, or strong burning?