Symptoms of G6PD deficiency in females

G6PD deficiency may cause no symptoms between episodes. During haemolysis, a person may notice sudden tiredness, weakness, dizziness, headache, breathlessness, a rapid heartbeat, yellow skin or eyes, or [Dark Urine](/symptoms/dark-urine/). The intensity depends on how quickly red cells are being removed and how much anaemia develops.

Females can be affected because they have two X chromosomes, and their enzyme activity can vary. [Pale Skin](/symptoms/pale-skin/) has many possible causes, so it should be assessed alongside the history, examination and testing.

Arrange medical advice promptly if symptoms appear after an infection or a new medicine. Bring the names or packaging of medicines, supplements and traditional remedies. A [Blood Test](/treatments/diagnostics-and-screening/blood-test/) can assess anaemia, red-cell breakdown and G6PD enzyme activity. Avoid self-starting medicines until a clinician confirms they are suitable for you.

Seek emergency care for severe breathlessness, fainting, confusion, chest discomfort, profound weakness, or a very fast heartbeat. Urgent review is also needed when dark urine appears with yellowing or worsening pallor. Tell the clinician that G6PD deficiency is known or suspected.

Ask which symptoms suggest haemolysis, which medicines and foods to avoid, whether your test was taken at the right time, and how to respond if symptoms return.