When is PGT-M recommended for recurrent miscarriage?

Recurrent miscarriage has many possible causes, and PGT-M is designed for one narrow situation: embryos are tested for a named inherited condition caused by a specific gene change. It does not investigate every reason a pregnancy may miscarry and is different from PGT-A, which looks for extra or missing chromosomes.

A genetics and fertility team may examine pregnancy tissue results, parental testing, family history, and prior specialist assessments. If no single-gene diagnosis is established, another evaluation may be more relevant than PGT-M.

Ask for genetic counselling before starting IVF. Bring reports from pregnancy tissue testing, previous genetic tests, and any diagnosis in the family. If a gene variant is confirmed, the laboratory can discuss whether a tailored PGT-M test is feasible and how long preparation may take.

Discuss what happens if embryos have no result, carry the condition, or are suitable for transfer. The team can also explain whether pregnancy testing would be advised after transfer.

During a pregnancy, seek urgent assessment for heavy bleeding, severe one-sided pain, shoulder-tip pain, dizziness, fainting, or fever. After miscarriage, prompt care is needed for worsening pain, heavy bleeding, fever, or feeling very unwell. These warning signs are separate from deciding about embryo testing.

Has testing identified a single-gene cause? Would PGT-M target that exact finding? What other miscarriage investigations remain relevant, and what pregnancy testing would follow an embryo transfer?