What to expect from PGT-M for recurrent miscarriage

PGT-M is designed for a specific inherited condition or genetic change already identified in a family. Recurrent miscarriage can have many possible explanations, so the team first reviews pregnancy history and genetic results rather than assuming that PGT-M is suitable.

A laboratory develops a test for the relevant family change, then examines cells from embryos created during IVF. Results can help distinguish embryos that do or do not carry the tested change, but they do not assess every possible cause of miscarriage or guarantee a pregnancy outcome.

Meet a fertility specialist and a genetic counsellor before treatment. Take family reports, previous genetic test results and pregnancy records if available. The IVF plan may include ovarian stimulation, egg collection, fertilisation, embryo growth and biopsy, followed by a period while the laboratory processes the test.

Ask how embryos will be classified, whether confirmatory testing is offered, and how transfer timing will be chosen. Discuss alternatives, including testing during pregnancy or trying without PGT-M, in language that fits your values.

Contact the clinic promptly for heavy bleeding, severe abdominal pain, breathing difficulty, fainting, fever or marked abdominal swelling during or after IVF medicines or egg collection. After embryo transfer, report bleeding or pain according to the clinic's instructions, and seek urgent help for severe symptoms.

What genetic change is being tested, and how was it confirmed in our family? What results might the laboratory report? How many appointments and procedures should we plan for? What are our options if no embryo is suitable for transfer?