What to Expect from Steroid Injection for Prurigo Nodularis

The clinician assesses the nodules and cleans the skin before using a fine needle to inject selected lesions. You may feel a sting, pressure, or burning, especially in thickened skin. The medicine is directed into the nodule to reduce local inflammation and itch, while the broader itch-scratch cycle may need additional care.

A treated nodule can be sore, swollen, or sensitive for a short time. The surface may remain thick while the underlying itch settles. Follow-up helps the clinician judge changes in itch, tenderness, thickness, and new lesion activity.

Follow instructions for cleaning and covering the injection points. Do not pick, squeeze, or scratch the nodules; protect them from friction and keep nails short. Tell the clinician about allergies, medicines, infection, and any pattern of nighttime itching so the plan can address more than the individual lesions.

Contact the treating clinic if redness, warmth, swelling, discharge, or pain is worsening, or if the skin becomes unusually thin or indented. Seek urgent care for breathing trouble, facial swelling, or widespread hives after the injection.

Ask which nodules are suitable, how to manage itch between visits, what improvement should be recorded, and when persistent or new nodules need reassessment.