What is the first treatment tried for syphilis?

Syphilis is an infection that can affect the skin, mucous membranes, nerves, eyes, and other organs. Testing helps confirm infection, while the examination and history help the clinician judge whether it is recent, longstanding, or of uncertain duration. That information affects the antibiotic plan. Treatment can stop the infection from progressing, but existing effects on organs may need separate assessment.

Arrange STI screening or a sexual-health assessment if you may have been exposed, have a new unexplained sore or rash, or have a partner diagnosed with syphilis. Avoid sexual contact until a clinician gives clear advice. Tell the clinician about pregnancy, medication allergies, neurological symptoms, and possible dates of exposure. Partners may need testing and treatment so infection is not passed back and forth.

Seek urgent care for eye pain or vision change, sudden hearing loss, severe headache, weakness, confusion, or difficulty walking. Contact a clinician promptly if you are pregnant or have a painless sore, spreading rash, or known exposure. After treatment, fever, chills, or worsening symptoms can occur and should be discussed, especially if severe.

Ask which tests are needed, what stage is suspected, how treatment will be given, when follow-up tests are due, and how partners should be contacted safely.