What is the first treatment for hormone receptor-positive breast cancer?

These cancers have receptors that can receive signals from hormones such as oestrogen or progesterone. Hormone therapy blocks those signals or lowers the hormone supply, which can slow cancer-cell growth. An aromatase inhibitor is one option, particularly after menopause; another hormone medicine may be selected in other circumstances.

The first step is not identical for everyone. The team considers whether the cancer is confined to the breast, whether lymph nodes are involved, menopausal status, previous treatment, and laboratory results. A CDK4/6 inhibitor may be added for some higher-risk or advanced cancers rather than used alone.

Ask which receptor results and stage are guiding the recommendation. Confirm the medicine name, how it is taken, expected treatment length, and how side effects will be monitored. Joint stiffness, hot flushes, tiredness, and changes in bone health can occur with hormone treatment, so discuss ways to protect mobility and bone strength.

If an operation is planned, ask how hormone therapy fits around it. Read about [Aromatase Inhibitor Therapy](/treatments/systemic-therapy/aromatase-inhibitor-therapy/) and [Hormone Therapy for Cancer](/treatments/systemic-therapy/hormone-therapy-for-cancer/) to understand the options.

Contact the oncology team promptly for sudden breathlessness, chest pain, one-sided leg swelling, severe weakness, or a new fever during treatment. Report persistent pain, unexpected bleeding, or mood and sleep changes as well; these symptoms may need assessment or a change in supportive care.

Which receptor and stage results determine my first treatment? What benefit is expected from hormone therapy in my situation? Do I need surgery, chemotherapy, or a CDK4/6 inhibitor as well? Which symptoms should prompt a same-day call?