Side effects of Anti-D injection

The injection contains Anti-D Immunoglobulin, which helps prevent your immune system from making antibodies against rhesus-positive blood cells during pregnancy or after a sensitising event. Soreness, warmth, mild swelling or itching where the injection was given can occur. Some people feel tired, develop a headache, or have a mild fever for a short time. These effects do not necessarily mean the medicine is harming you.

Keep the injection area clean and avoid rubbing it. Rest, drink fluids and check your temperature if you feel unwell. Tell your maternity team about symptoms that persist, worsen, or concern you. Do not take a new medicine for the reaction without checking that it is suitable in pregnancy. Keep your discharge or injection record so future clinicians know when Anti-D was given.

Call emergency services immediately for trouble breathing, swelling of the lips, tongue or throat, faintness, widespread hives, or sudden severe weakness. Contact your maternity unit promptly for a high fever, rapidly spreading redness, severe pain, or persistent vomiting. During pregnancy, vaginal bleeding, abdominal pain, fluid loss, or reduced fetal movement also needs prompt assessment, whether or not it began after the injection.

Ask why Anti-D was recommended, which symptoms are expected in your situation, and what treatment is safe if you develop discomfort. Confirm when you need the next dose and which warning signs should take you to urgent care.