Mupirocin for paronychia: what to know

Paronychia affects the skin beside or beneath a fingernail or toenail. The area may become red, tender, swollen, and warm; pus can develop. Mupirocin is a topical antibiotic for susceptible bacteria, so it is not suitable for every cause of nail-fold inflammation. Repeated wet work, nail biting, picking, manicures, or a yeast-related problem can change the treatment needed. A clinician can distinguish these patterns and check whether infection has collected under the skin.

Apply the prescribed amount to clean, dry skin and wash your hands around each application. Keep the finger or toe protected from biting, picking, harsh chemicals, and prolonged moisture; use gloves for wet tasks. Do not squeeze or pierce the swelling yourself. If pus is trapped, [Abscess Drainage](/treatments/minor-procedures/abscess-drainage/) may be considered by a trained clinician. Further information on [Antibiotics For Skin Infection](/treatments/medical-dermatology/antibiotic-therapy-for-skin-infection/) can help explain why the medicine should be used only as directed.

Seek prompt advice if pain becomes severe, swelling spreads along the finger or toe, movement is difficult, fever appears, or red streaking develops. Arrange a review if the nail changes shape, the problem keeps returning, or the area is not improving with the prescribed plan. People with diabetes or reduced immunity should seek advice early for a worsening nail-fold infection.

Ask whether the inflammation is bacterial, yeast-related, or caused by irritation; whether pus needs drainage; and how to apply the medicine around the nail. Ask what signs mean the infection has reached deeper tissue and how to prevent another episode.