What should you know about mifepristone and misoprostol?

Mifepristone reduces the effect of progesterone, a hormone that supports pregnancy. Misoprostol makes the uterus contract and helps the cervix open. Their sequence and route vary with the reason for treatment, so a general online schedule cannot replace a prescription or clinical assessment.

These medicines may be discussed for medical management of miscarriage or for induction of labour. They are not interchangeable, and symptoms alone cannot establish which pathway is appropriate. A clinician may need to assess pregnancy location, gestational details, bleeding and medical history first.

Before treatment, share your current medicines, allergies, blood-group information if known, prior caesarean or uterine surgery, bleeding conditions and any severe illness. Keep the written instructions accessible. Arrange the recommended follow-up and know how to contact the treating service outside normal hours.

Read the medicine overview for [Misoprostol](/materials/misoprostol/). Related care pathways include [Medical Management of Miscarriage](/treatments/medical-gynaecology/medical-management-of-miscarriage/) and [Induction of Labour](/treatments/pregnancy-and-birth-care/induction-of-labour/).

Get urgent help for collapse, faintness, severe abdominal pain, pain focused on one side, heavy bleeding, difficulty breathing or a high fever. Contact the clinical team about persistent severe pain, worsening weakness, an unpleasant-smelling discharge, or symptoms that differ from the instructions you received.

Ask why this combination is recommended, when each medicine should be used, which route is intended, what support is available for pain and nausea, and how completion of treatment will be checked.