Does immunotherapy treat squamous cell skin cancer?

Short answer
Immunotherapy can treat some advanced squamous cell skin cancers when surgery or radiotherapy is not suitable or sufficient.
This answers one question. It is not a diagnosis and does not replace an assessment by a licensed doctor.
At a glance
- Main role
- A possible systemic option for advanced disease
- Monitoring
- Skin review, examinations, and tests when indicated
What this means
Squamous cell skin cancer often begins as a local growth that can be managed with a procedure or focused treatment. If it has grown into nearby structures, returned after treatment, or spread, an immune-based medicine may be discussed. It works by helping immune cells recognise cancer, rather than by removing the visible growth directly.
The choice depends on the tumour's location and extent, previous procedures, general health, and medicines that affect the immune system. The team may examine the skin and nearby areas and use scans or other tests when needed. Follow-up checks look for both response and inflammation in healthy organs.
What to do next
Ask whether the cancer is local or advanced and why immunotherapy is being considered. Discuss other local options, the aim of treatment, how a response will be assessed, and how skin examinations will continue. Share any history of autoimmune illness, organ transplant, inflammatory bowel disease, or medicines such as steroids or other immune-suppressing treatments.
When to seek care
Tell your treatment team about a rapidly changing treated area, spreading redness, drainage, fever, severe diarrhoea, new cough, breathlessness, unusual tiredness, or a widespread rash. Get urgent help for severe breathing trouble, facial swelling, fainting, or sudden confusion. Early assessment helps distinguish infection, tumour changes, and treatment-related inflammation.
Questions for your doctor
Is my cancer advanced enough to need systemic treatment? Could surgery or radiotherapy still help? What skin and whole-body changes should I report? How will treatment affect my other conditions?
Questions people ask
Does every squamous cell skin cancer need immunotherapy?
No. Many local cancers are managed with local treatment; immunotherapy is considered only when the clinical situation supports it.
Can immunotherapy affect healthy skin?
It can cause inflammatory skin changes, so new rash, itching, or worsening redness should be discussed with the treatment team.
Keep reading
Cancer care in the UAE
Hospitals & Medical Centers in Abu Dhabi
Most UAE cancer care is delivered inside hospital services rather than by standalone oncology clinics, so these are licensed hospitals & medical centers listed in Abu Dhabi. Confirm the specific cancer service exists before you travel, and know that asking for a second opinion is routine.
Ahalia Hospital Musaffah Building - Musaffah - Musaffah Industrial - Abu Dhabi - United Arab Emirates
Accepts: Daman, Thiqa, AXA, Cigna +26 more
Al Ruwais Industrial City - Abu Dhabi - United Arab Emirates
Accepts: Daman, Thiqa, AXA, Cigna +30 more
Abu Dhabi, Abu Dhabi
Accepts: Daman, Thiqa, AXA, Cigna +30 more
Second opinions are routine in cancer care and asking for one does not affect your treatment. How to arrange a second opinion in the UAE.
Ordered by verification status and how complete each clinic's public record is, then alphabetically. This is a directory listing, not a ranking — Zavis does not rate or recommend providers.
A factual listing drawn from the DHA, DOH and MOHAP licence registers. It is not a referral, an endorsement, or advice that any of these providers is right for you.
Medical disclaimer. This page is general health information, not medical advice, and it cannot diagnose you. Always consult a licensed healthcare provider about your own symptoms and treatment. In an emergency in the UAE, call 998 for an ambulance.